Table 1

Studies of cigarette smoking and benign breast disease

First author, study yearStudy designNo. of cases/controls (or no. in cohort)Benign breast diseaseComparisonOR (95% CI)a
Rohan, 1999 (170)Cohort691/56,837Benign proliferative epithelial disorders of the breast>27.5 pack-years vs. never smoked0.9 (0.7–1.2)b
Rohan, 1999 (169)Cohort222/56,837Fibroadenoma>27.5 pack-years vs. never smoked0.7 (0.4–1.1)
Dziewulska-Bokiniec, 1995 (167)Case-Control160/160Fibroadenoma, dysplasia, fibrocystic disease, others20+ years duration of smoking vs. never0.8 (0.1–3.4)
Yu, 1992 (172)Case-Control117/117Fibroadenoma16+ years duration smoking vs. nonsmoker0.6 (0.3–1.4)c
Parazzini, 1991 (171)Case-Control288/291Dysplasia and benign tumors20+ years duration of smoking vs. never1.3 (0.7–2.6)d
Rohan, 1989 (168)Case-Control383/383Benign proliferative epithelial disorders of the breastCurrent smokers w/15+ pack-years vs. never smokers0.6 (0.3–1.1)e
  • a OR, odds ratio; CI, confidence interval.

  • b Results were similar when nonatypical cases were examined separately; the OR for atypical cases (>15 pack-years versus never smokers) was 1.3 (0.7–2.5).

  • c The results presented are based on population controls. The OR for biopsy controls was 1.3 (0.6–2.6).

  • d The results presented are for total cases and controls; the results were similar for dysplasia and benign tumors when analyzed separately.

  • e The OR when 192 biopsy controls were used instead of 383 community controls was 1.7 (0.7–4.2); the OR (current smokers versus never) for women with severe atypia was 2.3 (0.9–6.1).