Table 1

Pharmacokinetic parameters for EGCG, EGC, and EC after a single oral administration of GT, DGT, or EGCGa

Catechin and treatmentCmax ng/mlTmax hAUC ng · h/mlt1/2 h
EGCG
 GT191.69 ± 36.861.38 ± 0.37587.9 ± 200.63.76 ± 2.22
 GT289.80 ± 45.291.60 ± 1.05564.8 ± 333.43.08 ± 1.45
 GT352.30 ± 15.641.71 ± 0.93372.8 ± 147.73.37 ± 0.71
 DGT24.37 ± 15.761.20 ± 0.6790.5 ± 46.972.32 ± 2.55
 EGCG34.71 ± 22.871.61 ± 0.39213.7 ± 86.43.70 ± 2.22
EGC
 GT1208.1 ± 87.01.25 ± 0.61797.1 ± 355.31.37 ± 0.54
 GT2263.6 ± 139.31.39 ± 0.391081.9 ± 456.91.54 ± 0.48
 GT3198.4 ± 72.21.34 ± 0.47957.1 ± 503.12.15 ± 1.80
 DGT80.34 ± 22.261.09 ± 0.26294.9 ± 92.381.45 ± 0.65
EC
 GT1120.8 ± 67.61.26 ± 0.41436.5 ± 157.51.53 ± 0.73
 GT2133.0 ± 75.81.35 ± 0.34593.8 ± 286.92.06 ± 1.01
 GT3118.3 ± 73.71.18 ± 0.56558.2 ± 288.82.52 ± 1.95
 DGT32.53 ± 12.51.02 ± 0.19154.7 ± 72.32.51 ± 1.47
  • a The subjects were given an oral dose of GT or DGT (20 mg/kg) or EGCG (2 mg/kg). Blood samples were collected and treated as described in “Materials and Methods.” The data were analyzed, and the pharmacokinetic parameters were calculated using PCNONLIN. Data are the mean ± SD of eight subjects for GT and DGT and seven subjects for EGCG.