Table 3

Joint effects of CYP2E1 and salted/dried fish and oriental pickled vegetable intakes on CRC risk

SubsiteCYP2E1Salted/dried fish (g/day)aPeOriental pickled vegetables (g/day)bP
0>0≤Median>Median
ncORd (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)
ColonRsaI c1/c1 228/3861.043/631.1 (0.7–1.8)105/2291.0166/2201.7 (1.2–2.4)
Any c279/1660.8 (0.6–1.1)18/241.6 (0.8–3.0)0.2141/951.0 (0.6–1.6)56/951.4 (0.9–2.1)0.48
Insert 0 217/4021.044/661.3 (0.8–2.0)100/2371.0161/2311.7 (1.2–2.3)
1 or 284/1481.0 (0.7–1.5)16/211.5 (0.7–2.0)0.8842/871.1 (0.7–1.7)58/821.7 (1.1–2.7)0.94
RectumRsaI c1/c1 96/3861.024/631.5 (0.9–2.6)42/2291.078/2201.9 (1.2–3.0)
Any c238/1660.9 (0.6–1.4)7/241.1 (0.4–2.9)0.7415/950.9 (0.5–1.8)30/951.6 (0.9–2.9)0.88
Insert 0 87/4021.017/661.1 (0.6–2.0)38/2371.066/2311.7 (1.1–2.7)
1 or 245/1481.5 (1.0–2.4)13/213.0 (1.4–6.6)0.2618/871.4 (0.7–2.6)40/823.2 (1.8–5.7)0.40
  • a Salted and dried fish, including taegu.

  • b Includes tsukemono, kim chee, and other Oriental pickled vegetables. Median intake: 1.64 g/day.

  • c No. of cases/no. of controls.

  • d ORs (and 95% CIs) adjusted by unconditional logistic regression for age, sex, ethnicity, pack-years of cigarette smoking, lifetime recreational physical activity (hours), lifetime aspirin use (months), body mass index 5 years ago, years of schooling, and intakes of nonstarch polysaccharides from vegetables and calcium from foods and supplements.

  • e P for interaction based on the likelihood ratio test comparing the model with interaction with one containing only main effects for the two variables (test has 1 degree of freedom).