Table 2

Joint effects of CYP2E1 and RM and PM intakes on CRC risk

SubsiteCYP2E1RM (g/day) (without processed meats)aPMs (g/day)b
≤Median>MedianPc≤Median>MedianP
ncORd (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)
ColonRsaI c1/c1 118/2171.0153/2321.1 (0.8–1.5)107/2211.0164/2281.4 (1.0–1.9)
Any c256/981.1 (0.7–1.6)41/920.8 (0.5–1.2)0.1843/1020.9 (0.6–1.4)54/881.2 (0.6–1.4)0.81
Insert 0 126/2291.0135/2390.9 (0.7–1.3)101/2341.0160/2341.4 (1.0–2.0)
1 or 243/860.9 (0.6–1.4)57/831.1 (0.7–1.7)0.2843/871.1 (0.7–1.8)57/821.5 (0.9–2.3)0.79
RectumRsaI c1/c1 44/2171.076/2321.3 (0.8–2.0)38/2211.082/2281.7 (1.0–2.6)
Any c221/981.0 (0.5–1.8)24/921.1 (0.6–1.9)0.6414/1020.8 (0.4–1.6)31/881.6 (0.9–2.9)0.66
Insert 0 44/2291.060/2391.1 (0.7–1.7)35/2341.069/2341.5 (0.9–2.4)
1 or 220/861.3 (0.7–2.5)38/832.1 (1.2–3.7)0.3016/871.3 (0.6–2.5)42/823.1 (1.8–5.6)0.22
  • a All beef, pork, veal, and lamb items, except PMs. Median intake: 37.4 g/day.

  • b Ham, bacon, sausage, and luncheon meats. Median intake: 14.8 g/day.

  • c No. of cases/no. of controls.

  • d ORs (and 95% CIs) adjusted by unconditional logistic regression for age, sex, ethnicity, pack-years of cigarette smoking, lifetime recreational physical activity (hours), lifetime aspirin use (months), body mass index 5 years ago, years of schooling, and intakes of nonstarch polysaccharides from vegetables and calcium from foods and supplements.

  • e P for interaction based on the likelihood ratio test comparing the model with interaction with one containing only main effects for the two variables (test has 1 degree of freedom).