Table 3

Comparison of CYP17 genotype with grade/stagea among African-American prostate cancer patients

GenotypeLowHighOR95% CIPa
n = 37n = 34
TT 16 (43%)6 (18%)1.0 (Ref.)
TC 18 (49%)20 (58%)2.91.0–9.20.05
CC 3 (8%)8 (24%)7.11.4–36.10.01
TC + CC 21 (57%)28 (82%)3.61.2–10.60.01
  • a Grade/stage as defined as low (T1a–T1c stage and/or Gleason grade <7) or high (T2–T4 or N (+) or M (+) stage and Gleason grade ≥7).

  • bP from logistic regression analyses controlling for age, PSA, and family history.