Table 1

Lung cancer risk in relation to XPD codon 751 and XRCC3 codon 241 polymorphisms

GenotypeCaucasiansAfrican AmericansCombined
CasesControlsOR (95% CI)*CasesControlsOR (95% CI)CasesControlsOR (95% CI)
XPD codon 751
 Lys/Lys671971.00791301.001463271.00
 Lys/Gln771980.97 (0.62–1.52)63911.08 (0.66–1.76)1402891.03 (0.74–1.43)
 Gln/Gln34581.34 (0.74–2.42)11131.03 (0.40–2.65)45711.31 (0.80–2.15)
 Lys/Gln + Gln/Gln1112561.06 (0.70–1.61)741041.07 (0.67–1.71)1853601.08 (0.80–1.47)
XRCC3 codon 241
 Thr/Thr761751.00901361.001663111.00
 Thr/Met782100.93 (0.60–1.43)54880.90 (0.55–1.48)1322980.92 (0.67–1.28)
 Met/Met24680.94 (0.51–1.77)9101.67 (0.57–4.87)33781.08 (0.64–1.83)
 Thr/Met + Met/Met1022780.93 (0.62–1.41)63980.98 (0.61–1.56)1653760.95 (0.70–1.30)
Total178453153234331687
  • * ORs and 95% CIs are adjusted for age, sex, and smoking (the natural logarithm of pack-years and the product of the natural logarithm of pack-years and years since quitting smoking). The combined ORs are also adjusted for ethnicity.