Table 1

Geometric means (95% confidence intervals) of percentage methylation in colon adenocarcinomas for selected genes according to cancer subsite, age, race, and gender

APCCDKN2A (promoter)CDKN2A (exon 2)ESRIMLH1
Colon subsite
 Right (n = 27)7.3 (4.3, 11.9)3.9 (2.5, 5.9)31.3 (27.6, 35.4)24.8 (17.5, 35.0)10.8 (6.9, 16.5)
 Left (n = 35)7.4 (4.8, 11.2)3.8 (2.6, 5.4)31.4 (27.9, 35.3)30.9 (24.0, 39.7)8.0 (5.9, 10.8)
Pa0.910.990.720.200.27
Age
 <60 (n = 39)8.4 (5.5, 12.6)4.2 (3.1, 5.5)32.4 (29.2, 35.8)24.7 (18.4, 33.1)9.1 (6.7, 12.2)
 60+ (n = 23)5.8 (3.3, 9.6)3.3 (1.7, 5.7)29.8 (25.6, 34.6)34.7 (27.5, 43.9)9.1 (5.6, 14.5)
Pb0.760.240.280.020.38
Race
 Caucasian (n = 36)7.2 (4.5, 11.1)4.1 (2.8, 5.8)30.1 (27.0, 33.7)31.2 (24.1, 40.2)9.4 (6.8, 12.8)
 Non-Caucasian (n = 26)7.6 (4.7, 12.0)3.5 (2.2, 5.2)33.1 (29.1, 37.7)24.3 (17.2, 34.2)8.7 (5.6, 13.3)
Pa0.830.640.570.140.67
Gender
 Male (n = 20)8.5 (5.0, 14.1)4.3 (2.4, 7.2)33.4 (28.3, 39.5)25.5 (17.9, 36.4)10.0 (6.3, 15.5)
 Female (n = 42)6.8 (4.5, 10.3)3.6 (2.6, 4.9)30.4 (27.6, 33.5)29.4 (22.7, 37.9)8.7 (6.3, 11.9)
Pa0.530.600.560.470.80
  • a Ps for differences in methylation percentages by subsite, race, and gender were based on the Wilcoxon rank-sum test.

  • b Ps for the associations of methylation percentages with age were based on the test of Spearman rank order correlation coefficient = 0.0.