Table 2

DNA adduct levels in livers of Fischer 344 rats depending on dose and time after gavage

Differences in single and multiple gavage
DoseAdduct level (adducts/108 nucleotides)
mg/kgmmol/kgSingle gavageMultiple gavagea
20 h12 h
3004.33.4 ± 0.5b
3004.36.3 ± 0.25c
2002.92.9 ± 0.1b
2002.91.6 ± 0.6b
300.432.1 ± 0.4d
  • a Twenty h after the last gavage.

  • b Data from Budiawan et al. (26) .

  • c Thirty p.o. applications of 10 mg/kg body weight in 6 weeks.

  • d Thirty p.o. applications of 1 mg/kg body weight in 6 weeks.