Table 3

Genotypes of GSTM1, GSTT1, and EPHX as risk factors for HCC, stratified for peanut butter consumptiona

GenotypeORs and 95% CIs, age adjustedbORs and 95% CIs, multivariatec
LowaHighaLowaHigha
No. of cases/controlsOR (95% CI)No. of cases/controlsOR (95% CI)OR (95% CI)OR (95% CI)
All genotypes33/981.00 (Referent)78/962.62 (1.50–4.57)1.00 (Referent)2.50 (1.43–4.38)
GSTM1
 Present25/551.00 (Referent)37/601.57 (0.77–3.17)1.00 (Referent)1.43 (0.70–2.93)
 Null8/380.55 (0.21–1.47)39/352.75 (1.30–5.78)0.55 (0.21–1.47)2.60 (1.22–5.54)
GSTT1
 Present18/581.00 (Referent)51/592.71 (1.30–5.63)1.00 (Referent)2.71 (1.30–5.63)
 Null14/351.25 (0.51–3.11)25/362.28 (0.99–5.23)1.26 (0.51–3.11)2.28 (0.99–5.23)
EPHX exon 3
113YY22/651.00 (Referent)45/632.47 (1.24–4.94)1.00 (Referent)2.26 (1.12–4.56)
113YH6/240.74 (0.25–2.23)22/262.34 (1.02–5.38)0.66 (0.22–2.01)2.28 (0.99–5.25)
113HH4/81.47 (0.35–6.20)10/74.54 (1.33–15.49)1.35 (0.31–5.78)3.75 (1.07–13.12)
EPHX exon 4
139RR21/541.00 (Referent)41/481.90 (0.12–31.48)1.00 (Referent)1.70 (0.10–28.24)
139HR10/302.48 (0.24–25.30)34/397.85 (0.83–74.67)2.37 (0.23–24.07)7.18 (0.76–67.98)
139HH1/92.88 (0.30–27.44)2/46.54 (0.69–61.37)2.82 (0.30–26.80)6.02 (0.64–56.22)
EPHX exons 3 and 4 combined
 All other combinations29/891.00 (Referent)68/882.57 (1.43–4.62)1.00 (Referent)2.43 (1.34–4.39)
113HH and 139HH3/43.02 (0.51–18.01)9/37.68 (1.65–35.69)2.60 (0.41–16.69)6.31 (1.32–30.05)
  • a Low consumption defined as consumption of ≤135 g of peanut butter/month, high consumption defined as consumption of >135 g of peanut butter/month, based on the median consumption among controls.

  • b Adjusted for age (tertiles).

  • c Adjusted for age (tertiles) and region of origin.