Table 2

Genotypes of GSTM1, GSTT1, and EPHX and risk of HCC

OR (95% CI)
UnivariateAdjusted for ageMultivariatea
GSTM1
 Present1.00 (Referent)1.00 (Referent)1.00 (Referent)
 Null1.18 (0.73–1.90)1.26 (0.73–2.16)1.26 (0.73–2.19)
GSTT1
 Present1.00 (Referent)1.00 (Referent)1.00 (Referent)
 Null0.92 (0.56–1.50)0.94 (0.54–1.64)0.94 (0.54–1.65)
EPHX exon 3
113YY1.00 (Referent)1.00 (Referent)1.00 (Referent)
113YH1.05 (0.61–1.82)0.94 (0.51–1.73)0.93 (0.50–1.71)
113HH1.76 (0.80–3.85)1.68 (0.69–4.09)1.51 (0.61–3.75)
EPHX exon 4
139RR1.00 (Referent)1.00 (Referent)1.00 (Referent)
139HR2.75 (0.75–10.25)3.67 (0.89–15.06)3.63 (0.88–15.02)
139HH2.68 (0.73–9.76)3.19 (0.80–12.79)3.22 (0.80–13.01)
EPHX exon 3 and 4 combined
 All other combinations1.00 (Referent)1.00 (Referent)1.00 (Referent)
113HH and 139HH3.10 (1.18–8.12)2.97 (0.99–8.85)2.56 (0.83–7.95)
  • a Multivariate model adjusted for age (tertiles) and region of origin.