Table 5

Penetrances (f0, f1), RRHet, and PAF for the single-locus (additive) genetic model as a function of disease allele frequency p, assuming prevalence K = 1%

λMD)P = 0.001P = 0.005P = 0.01P = 0.05P = 0.10
4.0 (2.5)
 PAF7.7%17.4%24.6%56.2%81.6%
 RRHet43.022.017.313.823.2
 f00.00920.00830.00750.00440.0018
 f10.3960.1820.1310.06050.0426
7.4 (4.2)
 PAF11.3%25.4%36.0%82.1%
 RRHet64.835.029.146.8
 f00.00890.00750.00640.0018
 f10.5760.2610.1860.084