Table 3

Tissue polyamines

Treatment groupMean (SE)Mean Δ (SE) Day 28 to Day 1P for Δ vs. placeboP vs. 0.5 g
Day 1Day 28
A. Putrescine levels (nmol/skin biopsy)
1 g/day0.049 (0.026)0.062 (0.034)0.013 (0.041)0.30950.3095
0.5 g/day0.032 (0.006)0.020 (0.008)−0.012 (0.007)0.0411
Placebo0.012 (0.004)0.028 (0.006)0.016 (0.009)
B. Spermidine levels (nmol/skin biopsy)
1 g/day0.268 (0.024)0.313 (0.038)0.046 (0.047)0.81820.2972
0.5 g/day0.282 (0.055)0.254 (0.048)−0.027 (0.013)0.2972
Placebo0.208 (0.035)0.263 (0.017)0.055 (0.041)
C. Spermine levels (nmol/skin biopsy)
1 g/day0.939 (0.088)0.989 (0.135)0.050 (0.107)0.69910.3939
0.5 g/day0.861 (0.140)1.038 (0.187)0.176 (0.072)0.6991
Placebo0.910 (0.144)1.132 (0.072)0.222 (0.188)