Table 4

Percentage of samples with high molecular weight DNA and PCR success rates to amplify fragments of the β-globin gene from phase 2a of the study by method of collection

Method of collectionN% samples with high molecular weight DNAbPCR success rate
268 bp536 bp989 bp
Cytobrushes2860.7%c100%100%96.4%
Mouthwash25100.0%c100%100%96.0%
  • a Samples were collected from women participating in the WHS and extracted by phenol-chloroform.

  • b High molecular weight DNA was defined as grade 5 on the agarose gel (i.e., DNA fragments >23 kb).

  • c P < 0.001, cytobrush versus mouthwash Fisher’s exact test.