Table 1

Studies used for meta-analysisa

Location (reference)249ser/total number of HCCAny p53 mutation/total No. of HCCHBV+/total No. of HCC249ser+/HBV+249ser+/HBV−Any p53+/HBV+Any p53+/HBV−
High aflatoxin exposure regions
 Guangxi, China (53)nabna27/30nananana
 Guangxi, China (current study)18/50na28/388/242/5nana
 Jiang-Su, China (41)9/1611/1612/148/121/28/122/2
 Mozambique (22)8/15na15/158/150/0nana
 Mozambique (42)8/169/1314/167/141/18/121/1
 Mozambique (60)5/6na7/75/60/0nana
 Qidong, China (16)8/168/16nanananana
 Qidong, China (18)21/35na34/3621/330/2nana
 Qidong, China (19)9/209/2016/208/161/48/161/4
 Qidong, China (20)13/2515/2525/2513/250/015/250/0
 Qidong, China (61)7/147/1414/147/140/07/140/0
 Senegal (23)10/15na13/158/132/2nana
 Southern Africa (21)3/105/108/93/80/15/80/1
 Tongan, China (40)7/21na13/166/131/3nana
Moderate aflatoxin exposure regions
 Durban, South Africa (62)2/24nananananana
 Hong Kong, China (43)2/266/2628/312/240/26/240/2
 Mexico (46)3/16na11/201/61/9nana
 Shanghai, China (19)1/183/1815/181/150/33/150/3
 Shanghai, China (32)10/52na37/489/370/11nana
 Shanghai, China (44)1/122/127/120/71/52/71/5
 Shanghai, China (61)3/105/1010/103/100/05/100/0
 Taiwan (24)12/10227/10278/10512/750/2522/754/25
 Taiwan (39)4/6120/6141/614/410/2015/415/20
 Taiwan (63)3/3816/38nanananana
 Taiwan (64)0/133/1317/200/130/03/130/0
 Taiwan (65)3/15nananananana
 Thailand (45)1/152/157/131/70/62/70/6
 Transkei, South Africa (22)1/12na12/121/120/0nana
 Xian, China (44)1/452/1124/390/241/151/31/7
Low aflatoxin exposure regions
 Alaska, United States (66)0/130/1312/140/120/10/120/1
 Europe (67)0/141/144/140/40/100/41/10
 Europe (68)1/196/197/221/70/122/74/12
 Germany (69)0/132/134/130/40/90/42/9
 Germany (70)0/202/204/200/40/161/41/16
 Great Britain (71)0/192/196/190/60/130/62/13
 Italy (72)0/206/2012/200/120/85/121/8
 Japan (73)0/60na9/550/90/46nana
 Japan (65)0/6nananananana
 Japan (74)0/5218/5241/520/410/1110/418/11
 Japan (75)0/437/43nanananana
 Japan (76)0/5317/537/530/70/463/714/46
 Japan (77)0/203/208/200/80/121/82/12
 Japan (78)4/128nananananana
 Japan (79)3/3410/34nanananana
 Japan (80)0/4111/4110/410/90/272/99/27
 Northern China (41)1/154/155/91/50/43/51/4
 Singapore (81)0/4412/4431/440/310/1310/312/13
 Singapore (52)nana29/46nananana
 United States (82)4/37na5/373/51/32nana
  • a For the analysis of p53 249ser mutation or any p53 mutation and HBV status, we could only used tumors that had data for these two factors. Therefore, the total number of mutations within these analyses may not be the same as the total number of mutations observed when ignoring HBV status.

  • b na, data not available.