Table 3

Variables associated univariately with breast cancer death and development of invasive cancer in either breast after a primary DCIS of the breast

VariableBreast cancer death OR (95% CI) [cases/controls]Subsequent invasive cancer OR (95% CI) [cases/controls]
IpsilateralContralateral
Total[39/99][70/185][48/129]
Age
 <50 yr1.5 (0.5–4.3) [13/37]0.6 (0.3–1.2) [19/69]0.7 (0.3–1.6) [17/51]
 50–59 yrRefa [7/28]Ref [17/37]Ref [13/26]
 >59 yr2.5 (0.8–7.8) [19/34]1.2 (0.6–2.6) [34/79]0.7 (0.3–1.6) [18/52]
Mode of detection, mammography vs. clinical0.8 (0.3–2.0) [37/98]0.9 (0.4–1.8) [68/183]1.8 (0.7–4.3) [46/125]
Palpable, yes vs. no1.2 (0.5–2.6) [38/98]0.5 (0.3–1.0) [69/184]0.5 (0.2–1.1) [47/124]
Free margins, no or doubtful vs. yes1.7 (0.3–10.3) [30/84]1.3 (0.4–3.9) [45/160]9.8 (2.0–46.7) [42/111]
Size, ≥25 mm vs. <25 mm3.5 (1.1–11.4) [24/65]1.0 (0.4–2.2) [43/117]1.5 (0.6–4.0) [25/73]
Size, multifocal or multicentric vs. unifocal3.9 (1.2–12.7) [24/65]1.1 (0.5–2.5) [43/117]1.1 (0.5–2.7) [25/73]
Treatment
 BCSRef [13/32]Ref [48/60]Ref [10/29]
 BCS + XRT0.3 (0.0–2.9) [1/9]0.1 (0.0–0.8) [2/13]12.7 (1.4–115.8) [6/4]
 Mastectomy1.1 (0.5–2.8) [25/57]0.2 (0.1–0.4) [18/104]1.1 (0.5–2.5) [30/82]
  • a Ref, Reference group with an odds ratio 1.0.