Table 3

Lung cancer risk (OR and 95% CI) of VL versus other genotype groups at different pack-yearsa

Pack-yr of smokingPb
020406080100120
VL vs. other genotypes1.89 (1.08–3.28)1.11 (0.83–1.48)0.89 (0.66–1.19)0.75 (0.53–1.07)0.65 (0.42–1.00)0.57 (0.35–0.95)0.51 (0.29–0.91)<0.01
VL vs. low2.49 (1.26–4.92)1.19 (0.84–1.69)0.88 (0.62–1.24)0.69 (0.46–1.05)0.57 (0.34–0.94)0.48 (0.26–0.87)0.41 (0.21–0.81)<0.01
VL vs. intermediate1.74 (0.95–3.20)1.15 (0.84–1.58)0.97 (0.70–1.33)0.85 (0.58–1.25)0.76 (0.48–1.21)0.69 (0.40–1.19)0.63 (0.34–1.18)0.06
VL vs. high1.59 (0.80–3.14)0.95 (0.66–1.36)0.77 (0.53–1.11)0.65 (0.42–1.02)0.57 (0.33–0.97)0.50 (0.27–0.95)0.45 (0.22–0.93)0.04
  • a Logistic regression model including the following variables: age, gender, SR-PY, smoking status (current smokers, ex-smokers, and nonsmokers), years since smoking cessation, genotype, interaction between genotype and SR-PY, and interaction between smoking status and SR-PY.

  • b P for the interaction term between genotype groups and SR-PY in the logistic regression model.