Table 5

Stage-specific ORs for prostate cancer in relation to plasma levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3 in a Chinese population

IGF quartilesaLocalized diseaseAdvanced disease
n (cases/controls)OR (95% CI)n (cases/controls)OR (95% CI)
IGF-Ib
 Q15/731.0021/731.00
 Q29/764.77 (1.10–20.62)15/761.05 (0.43–2.59)
 Q313/757.63 (1.65–35.39)14/750.95 (0.35–2.53)
 Q420/7515.73 (3.04–81.94)27/752.17 (0.78–6.01)
Ptrend = 0.001Ptrend = 0.14
IGF-IIb
 Q18/711.0020/711.00
 Q217/773.90 (1.12–13.53)16/771.13 (0.42–3.04)
 Q314/752.81 (0.71–11.12)19/751.38 (0.48–3.92)
 Q48/761.88 (0.38–9.42)22/762.56 (0.78–8.42)
Ptrend = 0.83Ptrend = 0.11
IGFBP-1c
 Q115/751.0026/751.00
 Q28/750.49 (0.17–1.39)16/750.58 (0.27–1.27)
 Q311/750.55 (0.19–1.61)22/750.67 (0.31–1.45)
 Q413/740.48 (0.15–1.49)13/740.32 (0.13–0.81)
Ptrend = 0.21Ptrend = 0.03
IGFBP-3c
 Q112/761.0024/761.00
 Q210/760.29 (0.09–1.00)21/760.86 (0.38–1.92)
 Q313/750.40 (0.12–1.36)15/750.52 (0.20–1.36)
 Q413/770.31 (0.09–1.05)20/770.49 (0.18–1.33)
Ptrend = 0.20Ptrend = 0.12
IGF-I:IGFBP-3b
 Q16/741.0015/741.00
 Q26/760.83 (0.22–3.10)10/760.60 (0.22–1.61)
 Q39/741.34 (0.39–4.65)22/742.12 (0.92–4.87)
 Q426/756.30 (1.96–20.24)30/752.53 (1.11–5.78)
Ptrend < 0.001Ptrend = 0.003
  • a See Table 4<$REFLINK> for quartile ranges.

  • b Adjusted for IGFBP-1 and IGFBP-3 (quartiles), age, SHBG, and 3α-diol G (categories specified in Table 4<$REFLINK> ).

  • c Adjusted for IGF-I (quartiles), age, SHBG, and 3α-diol G (categories specified in Table 4<$REFLINK> ).