Table 4

ORs of prostate cancer in relation to plasma levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3 in a Chinese population

QuartileAdjusted for age onlyaAdjusted for age, IGFsbAdjusted for age, IGFs, SHBG, 3α-diol Gc
n (cases/controls)OR (95% CI)n (cases/controls)OR (95% CI)n (cases/controls)OR (95% CI)
IGF-IQ1 (<93.2 ng/ml)29/761.0026/731.0026/731.00
Q2 (93.2–123.2 ng/ml)24/770.79 (0.41–1.52)24/761.00 (0.49–2.03)24/761.52 (0.69–3.38)
Q3 (123.3–151.7 ng/ml)27/760.93 (0.49–1.77)27/761.39 (0.66–2.93)27/751.81 (0.77–4.23)
Q4 (>151.7 ng/ml)48/771.58 (0.87–2.88)48/752.63 (1.19–5.79)47/753.92 (1.58–9.70)
Ptrend = 0.09Ptrend = 0.01Ptrend = 0.003
IGF-IIQ1 (<343.5 ng/ml)29/761.0028/711.0028/711.00
Q2 (343.5–433.2 ng/ml)34/771.13 (0.61–2.09)33/771.16 (0.56–2.38)33/771.84 (0.81–4.17)
Q3 (433.3–521.9 ng/ml)35/761.20 (0.65–2.21)34/761.21 (0.56–2.62)33/751.95 (0.82–4.67)
Q4 (>521.9 ng/ml)30/771.01 (0.53–1.90)30/761.13 (0.48–2.68)30/762.22 (0.83–5.93)
Ptrend = 0.94Ptrend = 0.80Ptrend = 0.16
IGFBP-1Q1 (<61.7 ng/ml)41/751.0041/751.0041/751.00
Q2 (61.7–94.8 ng/ml)25/750.61 (0.33–1.13)25/750.62 (0.34–1.16)24/750.53 (0.27–1.04)
Q3 (94.9–149.0 ng/ml)33/750.80 (0.45–1.43)33/750.88 (0.48–1.60)33/750.62 (0.31–1.21)
Q4 (>149.0 ng/ml)26/750.54 (0.29–1.02)26/750.60 (0.31–1.17)26/740.40 (0.19–0.85)
Ptrend = 0.62Ptrend = 0.25Ptrend = 0.03
IGFBP-3Q1 (<2238.6 ng/ml)36/761.0036/761.0035/761.00
Q2 (2238.6–2813.0 ng/ml)31/760.97 (0.53–1.76)31/760.84 (0.45–1.58)31/760.70 (0.35–1.41)
Q3 (2813.1–3248.0 ng/ml)28/760.77 (0.42–1.42)28/760.55 (0.27–1.13)28/750.50 (0.23–1.11)
Q4 (>3248.0 ng/ml)33/770.90 (0.49–1.66)33/770.54 (0.26–1.15)33/770.47 (0.21–1.05)
Ptrend = 0.59Ptrend = 0.08Ptrend = 0.06
IGF-I:IGFBP-3dQ1 (<0.0362)24/761.0021/741.0021/741.00
Q2 (0.0362–0.0432)16/770.61 (0.29–1.26)16/760.71 (0.33–1.51)16/760.71 (0.31–1.61)
Q3 (0.0433–0.0519)31/751.24 (0.66–2.34)31/741.44 (0.74–2.80)31/741.91 (0.92–3.96)
Q4 (>0.0519)57/762.19 (1.21–3.96)57/762.51 (1.32–4.75)56/753.58 (1.74–7.35)
Ptrend = 0.001Ptrend < 0.001Ptrend < 0.001
  • a Adjusted for age (<60, 60–64, 65–69, 70–74, 75–79, 80–84, >84 years).

  • b Same as age, but IGF-I, IGF-II, and IGF-I:IGFBP-3 ratio adjusted for IGFBP-1 (quartiles) and IGFBP-3 (quartiles); IGFBP-1 and IGFBP-3 adjusted for IGF-I (quartiles).

  • c Same as (age plus IGFs) but further adjusted for SHBG (<319, 319–517, 518–742, >742 nmol/l) and 3α-diol G (<28, 28–36, 37–48, >48 ng/dl).

  • d Indirect measure of free IGF-I.