Table 3

Associations between MTHFR genotypes and lung cancer

GenotypeCases (n = 550)Controls (n = 554)ORa (95% CI)
C677Tb
 CC241 (43.8)245 (44.2)1.0
 CT252 (45.8)252 (45.5)1.1 (0.8–1.4)
 TT57 (10.4)57 (10.3)1.1 (0.7–1.7)
A1298Cc
 AA261 (47.5)265 (47.8)1.0
 AC246 (44.7)249 (45.0)1.0 (0.8–1.3)
 CC43 (7.8)40 (7.2)1.1 (0.7–1.8)
  • a ORs were adjusted for age, sex, smoking status, alcohol use, and calorie-adjusted folate intake in a logistic regression model.

  • b There was no difference in the C677T genotype distributions between cases and controls (P = 0.991).

  • c There was no difference in the A1298C genotype distributions between cases and controls (P = 0.931).