Table 2

MTHFR C677T and A1298C genotype distribution and allele frequencies in lung cancer patients and healthy controls

C677T (Ala → Val)Allele frequency
CC (%)CT (%)TT (%)CT
Cases (n = 550)
 A1298C (Glu → Ala)0.670.33
  AA (%)76 (14)128 (23)57 (10)
  AC (%)122 (22)124 (23)
  CC (%)43 (8)
 Allele frequency
  A0.70
  C0.30
Controls (n = 554a)
 A1298C (Glu → Ala)0.670.33
  AA (%)76 (14)132 (24)57 (10)
  AC (%)129 (23)120 (22)
  CC (%)40 (7)
 Allele frequency
  A0.70
  C0.30
  • a All the observed genotype frequencies for the C677T and A1298C polymorphisms in the controls were not statistically different from those (P = 0.900 and P = 0.430, respectively) calculated on the basis of Hardy-Weinberg’s equation (p2 + 2pq + q2).