Table 4

Numbers and median ages of ERCC2 genotypes in white tumor patients and controls, stratified by tumor histopathology in the San Francisco Bay Area Adult Glioma Study, 1991–1995

R156R (C to A)Genotypes and median agesORs
No. CA/CC (Median age)aNo. AA (Median age)OR (95% CI)Age/gender adjusted OR (95% CI)
Controls115 (52)24 (64)1.0b1.0b
All of the cases87 (47)39 (48)2.1 (1.2–3.8)2.3 (1.3–4.2)
 Glioblastoma multiforme31 (58)17 (63)2.6 (1.3–5.5)2.4 (1.1–5.0)
 Astrocytoma20 (41)9 (49)2.2 (0.9–5.3)2.8 (1.1–7.4)
 Oligoastrocytoma14 (40)8 (33)2.7 (1.0–7.2)3.2 (1.1–9.5)
D312N (G to A)No. GG (Median age)aNo. AG/AA (Median age)OR (95% CI)Age/gender adjusted OR (95% CI)
Controls56 (54)81 (52)1.0b1.0b
All of the cases67 (48)68 (46)0.7 (0.4–1.1)0.7 (0.5–1.2)
 Glioblastoma multiforme28 (60)23 (56)0.6 (0.3–1.1)0.6 (0.3–1.1)
 Astrocytoma13 (41)16 (43)0.9 (0.4–1.9)1.0 (0.4–2.2)
 Oligoastrocytoma16 (36)10 (36)0.4 (0.2–1.0)0.5 (0.2–1.3)
D711D (C to T)No. CC (Median age)aNo. CT/TT (Median age)OR (95% CI)Age/gender adjusted OR (95% CI)
Controls65 (54)75 (53)1.0b1.0b
All of the cases60 (48)54 (47)0.8 (0.5–1.3)0.8 (0.5–1.3)
 Glioblastoma multiforme24 (60)21 (57)0.8 (0.4–1.5)0.8 (0.4–1.6)
 Astrocytoma14 (46)10 (39)0.6 (0.3–1.5)0.6 (0.2–1.4)
 Oligoastrocytoma13 (32)6 (41)0.4 (0.1–1.1)0.4 (0.2–1.3)
K751Q (A to C)No. AA (Median age)aNo. AC/CC (Median age)OR (95% CI)Age/gender adjusted OR (95% CI)
Controls49 (52)99 (52)1.0b1.0b
All of the cases62 (49)86 (48)0.7 (0.4–1.1)0.7 (0.4–1.1)
 Glioblastoma multiforme28 (57)35 (58)0.6 (0.3–1.1)0.6 (0.3–1.1)
 Astrocytoma10 (50)22 (39)1.1 (0.5–2.5)1.1 (0.5–2.5)
 Oligoastrocytoma13 (32)12 (41)0.5 (0.2–1.1)0.5 (0.2–1.3)
  • a Age is age at diagnosis for cases and at interview for controls.

  • b Referent group.