Table 3

Frequencies of ERCC2 genotypes in white brain tumor patients and controls, stratified by tumor histopathology in the San Francisco Bay Area Adult Glioma Study, 1991–1995

Genotype-R156RAllele frequencies
CCaCAaAAaC (%)A (%)
Controls (n = 139)55 (40)60 (43)24 (17)61.138.8
All of the Cases (n = 126)38 (30)49 (39)39 (31)49.650.4
 Glioblastoma multiforme (n = 48)14 (29)17 (35)17 (35)46.953.1
 Astrocytoma (n = 29)8 (28)12 (41)9 (31)48.351.7
 Oligoastrocytoma (n = 22)8 (36)6 (27)8 (36)50.050.0
 Others (n = 27)8 (30)14 (52)5 (19)55.644.4
Genotype-D312NAllele frequencies
GGaGAaAAaG (%)A (%)
Controls (n = 137)56 (41)64 (47)17 (12)64.235.8
All of the Cases (n = 135)67 (50)51 (38)17 (13)59.727.4
 Glioblastoma multiforme (n = 51)28 (55)15 (29)8 (16)69.630.4
 Astrocytoma (n = 29)13 (45)12 (41)4 (14)65.534.4
 Oligoastrocytoma (n = 26)16 (62)8 (31)2 (8)76.923.1
 Others (n = 29)10 (34)16 (55)3 (10)62.137.9
Genotype-D711DAllele frequencies
CCaCTaTTaC (%)T (%)
Controls (n = 140)65 (46)59 (42)16 (11)67.532.5
All of the Cases (n = 114)60 (53)39 (34)15 (13)69.730.3
 Glioblastoma multiforme (n = 45)24 (53)16 (36)5 (11)71.128.9
 Astrocytoma (n = 24)14 (58)6 (25)4 (17)70.829.2
 Oligoastrocytoma (n = 19)13 (68)5 (26)1 (5)81.618.4
 Others (n = 26)9 (35)12 (46)5 (19)57.742.3
Genotype-K751QAllele frequencies
AAaACaCCaA (%)C (%)
Controls (n = 148)49 (33)76 (51)23 (16)58.841.2
All of the Cases (n = 148)62 (42)63 (43)23 (16)63.236.8
 Glioblastoma multiforme (n = 63)28 (44)26 (41)9 (14)65.134.9
 Astrocytoma (n = 32)10 (31)17 (53)5 (16)57.842.2
 Oligoastrocytoma (n = 25)13 (52)9 (36)3 (12)70.030.0
 Others (n = 28)11 (39)11 (39)6 (21)58.941.1
  • a Number in group (%).