Table 2

Comparison of molecular factors in tissue from breasts with low density and high density (n = 46 age matched pairs)

	Low density^a	High density^a	Difference (low-high)^b	P^c
Percentage of nuclear area (n = 46)	0.27^a (0.89)	0.85 (0.91)	−0.58 (1.40)	0.007
Percentage of total collagen^d (n = 41)	2.21 (1.66)	3.32 (1.56)	−1.11 (2.27)	0.003
Percentage of IGF-1^e (n = 45)	−0.29 (1.82)	0.48 (1.37)	−0.77 (2.15)	0.02
Percentage of TGF-α^e (n = 45)	−1.36 (2.05)	−1.49 (2.24)	0.12 (2.87)	0.77
Percentage of TIMP-3 (n = 46)	−0.99 (2.47)	−0.12 (2.49)	−0.86 (3.27)	0.08

^a Results expressed as mean (SD) of log-transformed values.
^b Paired differences (low-high density log-transformed value) expressed as mean (SD).
^c P for t-test for paired difference.
^d Values missing because of sections unsuitable for staining (n = 2) and staining measurement problems (n = 2).
^e Value missing because of sections unsuitable for staining (n = 1 for each measure).