Table 2

Crude and adjusted ORs of breast cancer in quintiles of serum enterolactone concentration

Quintiles of serum enterolactone concentrationP for trend
12345
All women, cutoff values, nmol/l<6.196.19–14.0814.19–24.3424.37–34.80>34.80
No. of cases4943363729
ORa (95% CI)1.000.68 (0.36–1.27)0.57 (0.30–1.07)0.57 (0.30–1.07)0.38 (0.20–0.73)0.01
ORb (95% CI)1.000.60 (0.30–1.17)0.57 (0.29–1.13)0.53 (0.27–1.05)0.38 (0.18–0.77)0.03
Premenopausal women, cutoff values, nmol/l<5.485.48–11.3711.66–20.2220.61–30.03>30.03
No. of cases1714131311
ORa (95% CI)1.000.61 (0.21–1.74)0.65 (0.21–1.93)0.57 (0.20–1.65)0.46 (0.15–1.34)0.26
ORb (95% CI)1.000.82 (0.22–3.09)0.39 (0.09–1.78)0.52 (0.14–2.00)0.42 (0.10–1.77)0.18
Postmenopausal women, cutoff values, nmol/l<6.306.33–14.9015.07–26.0126.11–37.65>37.65
No. of cases3229232418
ORa (95% CI)1.000.78 (0.36–1.71)0.50 (0.23–1.10)0.54 (0.25–1.19)0.35 (0.16–0.78)0.01
ORb (95% CI)1.001.19 (0.46–3.07)0.60 (0.24–1.49)0.80 (0.32–2.02)0.50 (0.19–1.28)0.10
  • a ORs adjusted for age and area.

  • b ORs adjusted further for age at menarche, age at first full-term pregnancy, use of oral contraceptives, use of estrogen replacement therapy, first-degree family history of breast cancer, history of benign breast disease, level of education, current alcohol intake, smoking habits, physical activity, waist:hip ratio, and body mass index.