Table 8

Adjusted ORs and 95% CIs for combinations of three putative GST high-risk genotypes and association with breast cancer

Case/controlORa (95% CI)
Premenopausal
GSTM1 GSTM3 GSTP1
  Present*A/*A Ile/Val or Val/Val20/291.0
  Null*A/*B or *B/*B Ile/Ile9/43.23 (0.82–12.7)
GSTM1 GSTM3 GSTT1
  Present*A/*A Present53/601.0
  Null*A/*B or *B/*B Null2/30.76 (0.10–5.54)
GSTM1 GSTP1 GSTT1
  Present Ile/Val or Val/Val Present26/381.0
  Null Ile/Ile Null8/43.96 (0.99–15.8)
GSTT1 GSTM3 GSTP1
  Present*A/*A Ile/Val or Val/Val47/621.0
  Null*A/*B or *B/*B Ile/Ile6/19.93 (1.10–90.0)
Postmenopausal
GSTM1 GSTM3 GSTP1
  Present*A/*B or *B/*B Ile/Val or Val/Val22/151.0
  Null*A/*A Ile/Ile67/491.08 (0.47–2.49)
GSTM1 GSTM3 GSTT1
  Present*A/*B or *B/*B Present45/491.0
  Null*A/*A Null13/121.26 (0.45–3.53)
GSTM1 GSTP1 GSTT1
  Present Ile/Val or Val/Val Present49/691.0
  Null Ile/Ile Null8/72.74 (0.81–9.32)
GSTT1 GSTM3 GSTP1
  Present*A/*B or *B/*B Ile/Val or Val/Val31/231.0
  Null*A/*A Ile/Ile16/151.08 (0.47–2.49)
  • a ORs adjusted for age, age at menarche, age at first full-term pregnancy, number of pregnancies, first-degree family history of breast cancer, and history of benign breast diseases.