Table 7

Adjusted ORs and 95% CIs for combinations of two putative GST high-risk genotypes and association with breast cancer

Case/controlORa (95% CI)
Premenopausalb
GSTM1 GSTM3
  Present*A/*A58/731.0
  Null*A/*B or *B/*B12/111.60 (0.63–4.11)
GSTM1 GSTP1
  Present Ile/Val or Val/Val30/441.0
  Null Ile/Ile 39/501.17 (0.60–2.26)
GSTM1 GSTT1
  Present Present77/891.0
  Null Null13/92.18 (0.84–5.68)
GSTP1 GSTM3
  Ile/Val or Val/Val*A/*A53/681.0
  Ile/Ile*A/*B or *B/*B30/212.07 (1.02–4.18)
GSTP1 GSTT1
  Ile/Val or Val/Val Present57/791.0
  Ile/Ile Null16/141.85 (0.79–4.30)
GSTT1 GSTM3
  Present*A/*A105/1391.0
  Null*A/*B or *B/*B9/62.58 (0.84–8.01)
Postmenopausalb
GSTM1 GSTM3
  Present*A/*B or *B/*B54/611.0
  Null*A/*A123/881.66 (0.99–2.77)
GSTM1 GSTP1
  Present Ile/Val or Val/Val63/761.0
  Null Ile/Ile76/561.85 (1.07–3.17)
GSTM1 GSTT1
  Present Present142/1471.0
  Null Null16/121.48 (0.60–3.65)
GSTP1 GSTM3
  Ile/Val or Val/Val*A/*B or *B/*B36/251.0
  Ile/Ile*A/*A143/991.08 (0.58–2.01)
GSTP1 GSTT1
  Ile/Val or Val/Val Present111/1121.0
  Ile/Ile Null23/261.17 (0.59–2.33)
GSTT1 GSTM3
  Present*A/*B or *B/*B65/651.0
  Null*A/*A33/261.37 (0.68–2.76)
  • a ORs adjusted for age, age at menarche, age at first full-term pregnancy, number of pregnancies, first-degree family history of breast cancer, and history of benign breast diseases.

  • b Tests for interaction between GST genotypes for pre- and postmenopausal women, respectively: GSTM1 and GSTM3, P = 0.841 and P = 0.869; GSTM1 and GSTP1, P = 0.695 and P = 0.249; GSTM1 and GSTT1, P = 0.117 and P = 0.581; GSTP1 and GSTM3, P = 0.035 and P = 0.012; GSTP1 and GSTT1, P = 0.893 and P = 0.518; GSTT1 and GSTM3, P = 0.633 and P = 0.680.