Table 4

ORs for breast cancer and smoking and breast cancer and radiation exposure stratified by XRCC1 codon 399 genotype among white participants

XRCC1 codon 399 genotype
Arg/Gln or Gln/GlnArg/Arg
Cases/ControlsOR (95% CI)aCases/ControlsOR (95% CI)a
Never smoker105/102Referent82/83Referent
Current smoker42 /470.9 (0.5–1.4)29 /330.9 (0.5–1.6)
Former smoker77 /681.0 (0.7–1.6)51 /481.1(0.7–1.9)
Duration of smoking (yr)
 Never105/102Referent82 /83Referent
 ≤1041 /331.0(0.6–1.8)16 /210.6 (0.3–1.3)
 11–2021 /330.6(0.3–1.1)23 /221.0 (0.5–2.0)
 >2057 /491.2(0.8–2.0)41 /381.3 (0.7–2.2)
P for trend test0.850.44
High-dose radiation to chest
 No207 /203Referent148 /155Referent
 Yes17 /141.2 (0.6–2.5)14 /91.9 (0.8–4.7)
Occupational exposure to ionizing radiation
 No211/211Referent147 /159Referent
 Yes13 /62.3(0.8–6.2)15 /53.3 (1.2–9.4)
  • a Adjusted for age.