Table 5

Association of COMT polymorphism and CYP1A1 (MspI), CYP1A1 (Ile/Val), CYP1A2, and CYP1B1 polymorphisms with the risk of ovarian cancer

GenotypeCOMTVal/ValCOMT–any MetPb for interaction
CasesControlsORa95% CICasesControlsORa95% CI
CYP1A1 (MspI)
m1/m119301c34461.20.5–2.6
 Any m231381.20.5–2.837302.00.9–4.50.53
CYP1A1 (Ile/Val)
A/A33451c57571.50.8–2.8
 Any G18231.00.4–2.315191.00.4–2.50.53
CYP1A2
A/A29311c44361.50.7–3.1
 Any C18310.80.4–1.925400.80.4–1.70.40
CYP1B1
Leu/Leu34481c32470.90.5–1.8
 Any Val18201.30.5–3.041292.61.2–5.50.17
  • a Adjusted by multiple unconditional logistic regression for age, ethnicity, education, pregnancy history, oral contraceptive pill use, history of tubal ligation, and regularity of menstrual cycles.

  • b Based on the likelihood ratio test comparing models with and without an interaction term.

  • c Reference category.