Table 3

Association of genetic polymorphisms and tobacco smoking with the risk of ovarian cancer

GenotypeNever smokedEver smokedPb for interaction
CasesControlsORa95% CICasesControlsORa95% CI
CYP1A1 (MspI)
m1/m135471c19290.80.4–1.9
 Any m236500.90.5–1.832182.61.2–6.00.03
CYP1A1 (Ile/Val)
A/A50641c40381.40.7–2.7
 Any G22330.70.4–1.51291.80.6–5.10.37
CYP1A2
A/A45521c28152.61.1–5.9
 Any C24420.70.4–1.319290.90.4–1.90.15
CYP1B1
Leu/Leu39631c28321.30.6–9.3
 Any Val37341.90.9–3.724153.81.6–9.80.54
COMT
Val/Val34451c18231.20.5–2.9
 Any Met39521.20.6–2.234242.21.0–4.70.36
  • a Adjusted by multiple unconditional logistic regression for age, ethnicity, education, pregnancy history, oral contraceptive pill use, history of tubal ligation, and regularity of menstrual cycles.

  • b Based on the likelihood ratio test comparing models with and without an interaction term.

  • c Reference category.