Table 1

Adjusteda mean hormone concentrations by CYP17 MspA1 I and SRD5A2 V89L polymorphisms in 622 British men

CYP17 geneSRD5A2 gene
A1/A1 n = 266A1/A2n = 273A2/A2n = 83PbV/Vn = 317V/Ln = 245L/Ln = 49Pb
Testosterone (nmol/liter)20.2 (19.4–21.1)21.0 (20.1–21.9)20.6 (19.1–22.2)0.44621.2 (20.4–22.0)c20.2 (19.4–21.1)18.7 (16.8–20.6)c0.037
FT (nmol/liter)0.43 (0.41–0.44)0.43 (0.42–0.45)0.42 (0.39–0.44)0.4770.44 (0.42–0.45)d0.43 (0.42–0.45)c0.37 (0.34–0.40)d,e0.001
A-diol-g (nmol/liter)8.90 (8.46–9.36)8.74 (8.31–9.19)8.13 (7.36–8.93)0.2568.82 (8.41–9.24)8.74 (8.27–9.21)7.96 (6.99–9.00)0.313
SHBG (nmol/liter)44.3 (42.1–46.7)46.3 (44.0–48.7)49.3 (45.0–54.2)0.12846.6 (44.5–48.9)44.3 (42.0–46.7)c50.7 (45.0–57.1)e0.093
LH (IU/liter)5.34 (5.04–5.66)5.06 (4.79–5.36)5.50 (4.96–6.10)0.2665.39 (5.11–5.68)5.29 (4.98–5.62)5.16 (4.51–5.91)0.809
  • a Values are adjusted for age (in categories of 20–29, 30–39, 40–49, 50–59, 60–69, 70+), time of day at venipuncture (<10, 10–13.29, 13.30+ h), time since last meal at venipuncture (<1.5, 1.5–<3, 3+ h), and time between blood draw and processing (1, 2, 3, 4+ days).

  • b P is test for heterogeneity across the mean hormone concentrations in each genotype (see text).

  • c Test of heterogeneity between two means; where two superscripts are the same, V/V genotype is different from V/L genotype at P < 0.05.

  • d Test of heterogeneity between two means; where two superscripts are the same, V/V genotype is different from L/L genotype at P < 0.05.

  • e Test of heterogeneity between two means; where two superscripts are the same, V/L genotype is different from L/L genotype at P < 0.05.