Table 1

Examples of disruption of tissue microarchitecture without dysplasia and vice versaa

Tissue disruption without epithelial cellular damageVerruca vulgaris
Hyperplastic polyps
Barrett metaplasia
Early ulcerative colitis
Epithelial cell dysplasia without tissue disruptionIntraepithelial neoplasia
Wound healing
  • a t is postulated (see text) that both components need to be disrupted for the development of cancer—a new 2-hit model.