Table 3

Association of SULT1A1 genotype with breast cancer, stratified by selected lifestyle factors among postmenopausal Iowa women

Variables (by median)aSULT1A1-Arg/ArgSULT1A1-Arg/HisSULT1A1-His/HisP for trend test
Cases/controlsORbCases/controlsOR (95% CI)cCases/controlsOR (95% CI)c
BMI
<26.18 kg/m224/641.036/721.3 (0.7–2.5)12/281.1 (0.5–2.6)0.60
≥26.18 kg/m231/841.035/641.5 (0.8–2.7)17/162.9 (1.3–6.5)<0.01
WHR
<0.8218/731.038/692.2 (1.2–4.3)12/212.3 (1.0–5.6)0.02
≥0.8237/751.033/671.0 (0.6–1.8)17/231.5 (0.7–3.2)0.37
Age at menopause (yrs)
<5024/741.038/622.1 (1.1–3.8)10/231.4 (0.6–3.4)0.17
≥5031/741.033/741.1 (0.6–2.0)19/212.2 (1.0–4.7)0.07
Age at menarche (yrs)
>1312/371.022/441.5 (0.6–3.5)6/111.7 (0.5–5.5)0.32
≤1343/1111.049/921.4 (0.9–2.3)23/331.9 (1.0–3.5)0.04
Alcohol drinking
No36/781.040/741.3 (0.7–2.3)13/251.3 (0.6–2.8)0.43
Yes19/701.031/621.8 (0.9–3.6)16/193.4 (1.4–7.9)<0.01
Age at first live birth (yrs)
<2219/731.033/602.1 (1.1–4.2)12/212.2 (0.9–5.3)0.03
≥2236/751.038/761.1 (0.6–1.9)17/231.6 (0.7–3.3)0.30
Parity
>235/1031.044/911.5 (0.9–2.5)15/311.5 (0.7–3.0)0.19
≤220/451.027/451.4 (0.7–2.8)14/132.4 (1.0–6.1)0.07
  • a Strata related to high endogenous estrogen exposure are shown in bold.

  • b Reference group.

  • c Adjusted for age, WHR, and number of live births, except where stratified.