Table 3

ORs for recurrence of DCIS

Nuclear morphometric featuresbHigh fractal2_areacLow fractal2_aread
OR (95% CI)POR (95% CI)P
A. ORsa for recurrence based on means of individual morphometric features
Low area1.01.0
High area2.90 (0.31–27.2)0.350.61 (0.09–4.21)0.61
Low eccentricity1.01.0
High eccentricity1.15 (0.24–5.5)0.872.9 (0.77–11.56)0.11
Low elongation1.01.0
High elongation1.33 (0.28–6.3)0.724.02 (1.04–15.63)0.04
Low sphericity1.01.0
High sphericity1.0 (0.20–4.89)0.990.36 (0.10–1.36)0.13
Low compactness1.01.0
High compactness1.17 (0.24–5.77)0.853.0 (0.70–12.98)0.14
Low var_radi1.01.0
High var_radi4.55 (0.45–45.96)0.204.93 (0.86–28.25)0.07
Low freq_high_fft1.01.0
High freq_high_fft3.86 (0.88–16.98)0.071.17 (0.31–4.47)0.82
Low freq_low_fft1.01
High freq_low_fft2.55 (0.43–14.98)0.303.15 (0.83–11.88)0.09
B. ORsa for recurrence based on variances of individual morphometric features
Low area1.01.0
High area0.96 (0.14–6.80)0.970.24 (0.02–2.78)0.25
Low eccentricity1.01.0
High eccentricity2.17 (0.41–11.51)0.364.73 (1.24–18.05)0.02
Low elongation1.01.0
High elongation1.84 (0.35–9.63)0.474.21 (1.13–15.78)0.03
Low sphericity1.01.0
High sphericity3.00 (0.55–16.40)0.215.76 (1.38–23.94)0.02
Low compactness1.01.0
High compactness1.70 (0.32–8.94)0.532.67 (0.70–10.16)0.15
Low var_radi1.01.0
High var_radi4.24 (0.35–51.20)0.264.62 (0.77–27.55)0.09
Low freq_high_fft1.01.0
High freq_high_fft1.17 (0.27–5.14)0.844.80 (1.24–18.67)0.02
Low freq_low_fft1.01.0
High freq_low_fft2.04 (0.41–10.34)0.391.66 (0.44–6.25)0.45
  • a Odds ratios are adjusted for age at diagnosis, follow-up intervals, radiotherapy, and nuclear grade.

  • b High value is defined by a value above the median of the whole group (excluding grade 1) subjects.

  • c Represents 11 recurrent and 36 non-recurrent subjects.

  • d Represents 18 recurrent and 37 non-recurrent subjects.