Table 4

XRCC1 codon 194 and 399 polymorphisms and smoking, stratified analysis

Years smokedGenotypeWhitesBlacksCombined
CasesControlsORadja95% CITest for Interaction PadjaCasesControlsORadjb95% CITest for interaction Padjb
Codon 194c
>34 CC 83361ref731ref
>34 CT 1241.30.4–4.2001.30.4–4.3
1–34 CC 72650.50.3–0.9950.60.3–0.9
1–34 CT 11200.30.1–0.60.21010.20.1–0.60.16
0 CC 33610.20.1–0.3120.20.1–0.3
0 CT 2100.10.0–0.40.25120.10.0–0.30.26
Codon 399d
>34 GG+GA 84371ref731ref
>34 AA 1131.60.4–6.3001.70.4–6.4
1–34 GG+GA 77730.50.3–0.8960.50.3–0.9
1–34 AA 6120.20.1–0.70.18000.30.1–0.80.16
0 GG+GA 32600.20.1–0.4240.20.1–0.4
0 AA 3110.10.0–0.30.18000.10.0–0.30.17
  • a Adjusted for age and sex.

  • b Adjusted for age, sex, and ethnicity.

  • c Codon 194 (base pair 26304) C to T change, Arginine to Tryptophan amino acid change.

  • d Codon 399 (base pair 28152) G to A change, Arginine to Glutamine amino acid change.