Table 2

Genotypic frequencies and bladder cancer risk

GenotypeWhitesBlacksbCombined
Cases (%)Controls (%)ORadja95% CICasesControlsORadjc95% CI
Codon 194d
CC 189 (88)163 (83)1ref18 (95)10 (77)1ref
CT 24 (12)34 (17)0.60.4–1.11 (5)3 (23)0.60.3–1.0
TT 0 (0)0 (0)0 (0)0 (0)
Codon 280e
GG 198 (92)180 (92)1ref17 (89)13 (100)1ref
GA 16 (8)13 (7)1.10.5–2.42 (11)0 (0)1.20.6–2.6
AA 0 (0)2 (1)0 (0)0 (0)
GG 198 (92)180 (92)1ref17 (89)13 (100)1ref
GA+AA 16 (8)15 (8)1.00.5–2.02 (11)0 (0)1.10.5–2.2
Codon 399f
GG 87 (40)79 (40)1ref9 (47)9 (69)1ref
GA 106 (50)92 (47)1.00.6–1.610 (53)4 (31)1.10.7–1.6
AA 21 (10)26 (13)0.70.4–1.40 (0)0 (0)0.70.4–1.4
GG+GA 193 (90)171 (87)1ref19 (100)13 (100)1ref
AA 21 (10)26 (13)0.70.4–1.30 (0)0 (0)0.70.4–1.3
  • a Adjusted for age and sex.

  • b We omitted the ORs and CIs for black subjects because of the presence of relatively few subjects.

  • c Adjusted for age, sex, and ethnicity.

  • d Codon 194 (base pair 26304) C to T change, Arginine to Tryptophan amino acid change.

  • e Codon 280 (base pair 27466) G to A change, Arginine to Histidine amino acid change.

  • f Codon 399 (base pair 28152) G to A change, Arginine to Glutamine amino acid change.