Table 4

Stratified analyses of the association between XRCC1 variants and lung cancer riska

Arg194TrpbArg280HisbArg399Glnb
WTc-Arg OR [Cases/Controls]VT-Trp OR (95% CI) [Cases/Controls]WT-Arg OR [Cases/Controls]VT-His OR (95% CI) [Cases/Controls]WT-Arg OR [Cases/Controls]VT-Gln OR (95% CI) [Cases/Controls]
Alcohol (g/day)
Nondrinkers (0)1 [21/48]1.1 (0.5–2.1) [33/63]1 [44/87]0.8 (0.3–1.9) [9/23]1 [32/58]0.8 (0.4–1.5) [22/52]
Drinkers (>10)1 [31/37]0.4 (0.2–0.9) [23/62]1 [39/90]3.7 (1.5–9.5) [14/9]1 [27/59]1.2 (0.5–2.6) [26/39]
  • a All unmatched logistic regression models adjusted for age at baseline, sex, radon exposure, and tobacco exposure (pack-year equivalents).

  • b P for interaction for alcohol: Arg194Trp, 0.04; Arg280His, 0.02; Arg399Gln, 0.18.

  • c WT, homozygous wild-type; VT, heterozygous and homozygous variant.