Table 3

Association between XRCC1 genotype profile and lung cancer risk

Exon 6Exon 9Exon 10CasesControlsOR (95% CI; P)
UnadjustedAdjusteda
All wild-type genotypes
WTbWTWT13301.0 (Reference)c1.0 (Reference)c
One variant polymorphism
VTWTWT28631.1 (0.5–2.4; 0.76)1.2 (0.6–2.5; 0.67)
WTVTWT982.9 (0.9–8.8; 0.06)2.9 (0.9–9.2; 0.07)
WTWTVT23381.5 (0.7–3.4; 0.29)1.6 (0.7–3.5; 0.28)
Two variant polymorphisms
VTVTWT8161.2 (0.5–3.6; 0.66)1.3 (0.5–3.9; 0.59)
WTVTVT681.9 (0.6–6.4; 0.30)2.0 (0.6–7.1; 0.32)
VTWTVT19451.1 (0.5–2.4; 0.87)1.1 (0.5–2.4; 0.87)
Three variant polymorphisms
VTVTVT00
  • a All unconditional logistic regression models adjusted for age, sex, radon and tobacco exposure (pack-year equivalents) modeled as a continuous term.

  • b WT, homozygous wild type; VT, heterozygous and homozygous variant.

  • c Used as reference group.