Table 2

Association between the XRCC1 polymorphisms and lung cancer riska

XRCC1 genotypeCases, n (%)Controls, n (%)χ2POR
UnadjustedAdjusted
Exon 6, codon 194
Arg/Arg52 (48%)85 (40%)1.0 (Ref)b1.0 (Ref)
Arg/Trp47 (44%)104 (50%)0.420.7 (0.4–1.2)0.7 (0.4–1.2)
Trp/Trp9 (8%)21 (10%)0.7 (0.3–1.6)0.7 (0.3–1.8)
Arg/Trp+ Trp/Trp56 (52%)125 (60%)0.190.7 (0.5–1.2)0.7 (0.4–1.2)
Exon 9, codon 280
Arg/Arg83 (78%)177 (85%)1.0 (Ref)1.0 (Ref)
Arg/His20 (19%)32 (15%)0.031.4 (0.7–2.6)1.6 (0.8–3.1)
His/His3 (3%)0 (0%)NCcNC
Arg/His+ His/His23 (22%)32 (15%)0.161.6 (0.9–2.9)1.8 (1.0–3.4)
Exon 10, codon 399
Arg/Arg59 (55%)117 (54%)1.0 (Ref)1.0 (Ref)
Arg/Gln40 (37%)80 (37%)0.741.0 (0.6–1.6)1.0 (0.6–1.6)
Gln/Gln8 (7%)11 (5%)1.4 (0.5–3.7)1.3 (0.5–3.5)
Arg/Gln+ Gln/Gln48 (44%)91 (42%)0.851.0 (0.6–1.6)1.0 (0.6–1.6)
  • a All conditional logistic regression models adjusted for radon and tobacco exposure (pack-year equivalents) modeled as a continuous term.

  • b Ref, used as reference group.

  • c NC, OR not calculable with conditional logistic regression (all 3 homozygous variant individuals developed lung cancer).