Table 1

Test characteristics (with 95% confidence intervals) of the different screening methods for chronic atrophic gastritisa

Sensitivity (%)Specificity (%)Predictive value positive (%)Predictive value negative (%)
H. pylori antibodies91.7 (86.8–94.9)18.0 (13.2–24.1)72.5 (65.8–78.4)44.4 (40.9–54.9)
CagA antibodies82.6 (76.6–87.4)41.0 (34.2–48.1)76.8 (70.3–82.3)50.0 (43.0–57.0)
Gastrin ≥25 ng/lb82.6 (76.6–87.4)21.7 (16.4–28.1)71.7 (64.9–77.7)34.2 (27.8–41.2)
PGI <25 μg/lb5.8 (2.8–11.2)100 (96.9–100)100 (96.9–100)32.2 (24.9–40.4)
PGI/PGII <2.5b13.7 (8.8–20.6)95.7 (90.6–98.2)87.5 (80.8–92.2)33.3 (25.9–41.6)
Age ≥60 years25.7 (20.0–32.3)88.5 (83.2–92.4)84.1 (78.2–88.7)33.5 (27.2–40.5)
CagA antibodies+ gastrin ≥25 ng/l69.4 (62.6–75.6)46.7 (39.7–53.8)75.8 (69.2–81.4)38.9 (32.2–46.0)
CagA antibodies+ PGI <25 μg/l4.9 (2.2–10.0)100 (96.9–100)100 (96.9–100)31.9 (24.7–40.2)
CagA antibodies+ PGI/PGII <2.511.8 (7.3–18.3)95.7 (90.6–98.2)85.7 (78.8–90.7)32.8 (25.5–41.1)
PGI <25 μg/l+ gastrin ≥25 ng/l5.8 (2.8–11.2)100 (96.9–100)100 (96.9–100)32.2 (24.9–40.4)
PGI/PGII <2.5+ gastrin ≥25 ng/l11.8 (7.3–18.3)95.7 (90.6–98.2)85.7 (78.2–90.3)32.8 (25.5–41.1)
CagA antibodies+ Age ≥60 years20.1 (15.0–26.4)96.7 (93.0–98.6)93.6 (89.0–96.4)33.9 (27.6–40.9)
  • a None vs. mild/moderate/severe.

  • b One person was not tested for gastrin, 56 were not tested for PGI, and 57 were not tested for PGII levels.