Table 3

AUC of total catechins (sum of unchanged and conjugated forms) after oral administration of EGCG or Polyphenon E

Dose levels
200 mga400 mgb600 mgc800 mgd
EGCG formulation
EGCG AUC (min·μg/ml)22.0 ± 8.8e37.3 ± 25.4132.6 ± 149.9166.4 ± 70.7
Polyphenon E formulation
EGCG AUC (min·μg/ml)23.0 ± 7.8f64.9 ± 32.8f111.1 ± 66.3f258.2 ± 111.0
EGC AUC (min·μg/ml)34.7 ± 10.0f47.1 ± 23.3f61.3 ± 22.0f94.3 ± 8.2
EC AUC (min·μg/ml)39.0 ± 10.5f52.4 ± 31.2f90.8 ± 35.7f167.8 ± 43.9
  • a 200 mg of EGCG in the EGCG formulation; 200 mg of EGCG, 37 mg of EGC, and 31 mg of EC in the Polyphenon E formulation.

  • b Twice the tea polyphenol contents compared with the 200-mg dose.

  • c Three times the tea polyphenol contents compared with the 200-mg dose.

  • d Four times the tea polyphenol contents compared with the 200-mg dose.

  • e Mean ± 1 SD.

  • f Significantly different from the 800-mg dose level (P < 0.05).