Table 2

Pharmacokinetic parameters of EGCG after oral administration of EGCG or Polyphenon E

Parameter200 mg400 mg600 mg800 mg
EGCGPolyphenon EEGCGPolyphenon EEGCGPolyphenon EEGCGPolyphenon E
AUC (min·μg/ml)22.5 ± 7.3a,b21.9 ± 12.0c35.4 ± 21.5b52.2 ± 22.8c101.9 ± 99.779.7 ± 39.2c167.1 ± 57.0161.4 ± 57.0
Cmax (ng/ml)73.7 ± 25.3b72.7 ± 66.4c111.8 ± 98.6b125.3 ± 50.4c169.1 ± 139.6165.7 ± 126.9c438.5 ± 284.4377.6 ± 149.8
Tmax (min)127.1 ± 76.6144.7 ± 90.7108.7 ± 26.4170.9 ± 64.7180.0 ± 84.8216.0 ± 53.7240.6 ± 84.6249.0 ± 85.4
CL/F (liters/min)11.4 ± 4.314.6 ± 10.118.0 ± 10.210.7 ± 5.612.8 ± 12.510.3 ± 4.86.0 ± 1.76.5 ± 1.8
Vβ/F (liters)2009 ± 15143068 ± 22294774 ± 35822760 ± 22114368 ± 58832544 ± 14141044 ± 5431091 ± 438
t1/2 (min)118.0 ± 77.0156.9 ± 96.2162.3 ± 84.3180.5 ± 112.3183.7 ± 67.6163.1 ± 31.8114.0 ± 33.3113.5 ± 20.6
λn (min−1)0.0085 ± 0.00580.0059 ± 0.00310.0054 ± 0.00300.0051 ± 0.00280.0041 ± 0.00120.0044 ± 0.00110.0065 ± 0.00190.0063 ± 0.0010
  • a Mean ± 1 SD.

  • b Significantly different from that of 800 mg of EGCG, P < 0.05.

  • c Significantly different from that of 800 mg of Polyphenon E, P < 0.05.