Table 1

Relationship of alcohol intake and risk of colorectal cancer according to ADH3 genotype

OverallADH3 GenotypeP, trend
ADH31-1ADH31-2ADH32-2
RRa (95% CI) [No. case, No. control]RR (95% CI) [No. case, No. control]RR (95% CI) [No. case, No. control]RR (95% CI) [No. case, No. control]
Overall1.0 (referent) [86, 426]0.92 (0.67–1.27) [96, 513]0.83 (0.53–1.31) [29, 174]0.40
Alcohol consumption (drinks/week)
 ≤11.0 (referent) [61, 397]1.0 (referent) [28, 167]1.09 (0.62–1.91) [28, 162]0.44 (0.16–1.20) [5, 68]0.20
 2–41.51 (1.05–2.17) [84, 369]1.54 (0.88–2.71) [31, 128]1.42 (0.84–2.40) [41, 184]1.38 (0.66–2.90) [12, 57]0.68
 ≥51.25 (0.85–1.84) [66, 338]1.31 (0.73–2.35) [27, 127]1.00 (0.56–1.78) [27, 163]1.63 (0.77–3.45) [12, 48]0.94
P, trend0.250.590.810.04
  • a RR adjusted for age, smoking status, use of aspirin, and multivitamins.