Table 4

ORs for oral cancer in relation to ADH3 and GSTM1 genotypes, by alcohol consumption

ORsa and 95% CIs
[No. cases, no. controls]
Genotypes<1 drinks/wk1–14 drinks/wk15–28 drinks/wk29+ drinks/wkTotal
[45, 141][137, 307][58, 52][88, 35][328, 535]
ADH3*2/*2 & GSTM1 not null
or1.01.01.01.01.0
ADH3*1/*2 & GSTM1 not null
ADH3*2/*2 & GSTM1 null
or
ADH3*1/*2 & GSTM1 null1.3 (0.6, 3.0)1.1 (0.7, 1.9)1.8 (0.7, 4.1)0.9 (0.4, 2.4)1.2 (0.9, 1.7)
or
ADH3*1/*1 & GSTM1 not null
ADH3*1/*1 & GSTM1 null1.5 (0.6, 4.2)1.0 (0.5, 1.8)1.9 (0.5, 6.3)0.8 (0.2, 2.7)1.1 (0.7, 1.8)
  • a ORs are adjusted for age (continuous years), sex, race (white, nonwhite), and cigarette smoking (continuous pack-years).