Table 3

Joint association of ADH3 genotype, average weekly alcohol intake, and risk of oral cancer, Seattle-Puget Sound region, 1985–1995

ADH3 genotypeOR (95% CI)a [No. cases, no. controls]
<1 drink/wk1–14 drinks/wk15–28 drinks/wk≥29 drinks/wkTotalb
*1/*1 2.1 (0.8, 5.9)2.0 (0.8, 5.3)3.4 (1.1, 10.8)6.1 (1.9, 19.5)1.3 (0.8, 2.0)
[20, 52][52, 115][18, 17][25, 13][115, 197]
*1/*2 1.7 (0.6, 4.7)2.1 (0.8, 5.3)3.9 (1.3, 11.8)8.7 (2.9, 26.1)1.3 (0.9, 2.0)
[20, 59][67, 138][28, 22][44, 17][159, 234]
*2/*2 1.01.4 (0.5, 4.1)3.4 (1.0, 11.5)10.0 (2.5, 40.2)1.0
[6, 32][21, 59][12, 14][20, 5][59, 110]
Totalc1.01.1 (0.7, 1.7)2.2 (1.2, 3.9)4.7 (2.6, 8.5)
[46, 141][140, 312][58, 53][89, 35]
  • a ORs estimated jointly within categories of ADH3 genotypes and alcohol consumption are adjusted for age (continuous years), race (white, nonwhite), and cigarette smoking (continuous peak-years).

  • b ORs also adjusted for alcohol consumption (categories indicated in Table).

  • c ORs also adjusted for ADH3 genotype.