Table 1

Distribution and age- and gender-adjusted OR and 95% CI for colorectal adenomas for serum 25-OHD, sun exposure, intake of vitamin D, intake of calcium, and VDR FokI polymorphism

No. of subjectsMedian (10th and 90th percentile)OR95% CI
CasesControlsCasesControls
Serum vitamin D (ng/ml)
 Overalla23621824.7 (12.7, 36.6)26.5 (15.2, 39.4)0.74b0.60, 0.92
  Samples drawn in summer/falla13312426.9 (15.0, 41.1)29.0 (18.4, 40.2)0.77b0.58, 1.01
  Samples drawn in winter/springa1039420.9 (11.8, 32.2)23.1 (34.9, 13.4)0.70b0.70, 1.01
 Non-Hispanic Caucasiansa21119725.5 (14.3, 36.6)27.1 (16.3, 39.7)0.74b0.58, 0.95
 Other than non-Hispanic Caucasiansa252115.4 (9.7, 28.7)17.4 (11.8, 31.3)0.59b0.28, 1.23
Sun exposure (h/yr)
 Over the whole yr239228325 (52, 1092)325 (39, 1001)1.00c0.96, 1.04
  In the summer23922891 (26, 364)91 (13, 325)1.05c0.92, 1.19
Vitamin D intake (IU/day)
 Total vitamin D239228254 (53, 669)385 (68, 692)0.98c0.93, 1.03
  Dietary vitamin D239228140 (56, 266)142 (53, 292)0.87c0.71, 1.07
  Supplement vitamin D2392280 (0, 400)114 (0, 400)0.99c0.94, 1.04
Calcium intake (mg/day)d
 Total calcium146228712 (332, 1511)804 (359, 1645)0.97c0.93, 1.01
  Dietary calcium146228549 (283, 1033)607 (276, 1213)0.93c0.88, 1.00
  Supplement calcium146228112 (0, 730)130 (0, 1000)0.99c0.94, 1.05
VDR FokI Genotypee
 ff21161.00
 Ff115950.920.45, 1.89
 FF72730.750.36, 1.58
  • a Additional adjusted for season when blood was drawn (summer or fall vs. winter or spring).

  • b OR and 95% CI per 10 units increase.

  • c OR and 95% CI per 100 units increase.

  • d Limited to cases without previous adenoma.

  • e Additional adjusted for ethnicity.