Table 3

OR of lung cancer for asbestos exposure, GSTM1 genotype, and their interaction

StudyAsbestosGSTM1Interaction
CasesControlsORa95% CIbCasesControlsORd95% CIE++eORa95% CI
E+E−E+E−NullPresentcNullPresentCasesControls
(US Cauc)34111583222.01.1–3.670751991811.10.7–1.828171.10.4–3.2
(US-AA)3091421502.01.0–3.83190601320.80.4–1.412111.70.5–6.2
(France 1)18221162261.10.5–2.21261131111311.40.9–2.0870.80.2–3.6
(France 2)28118111583.71.7–7.9806688811.10.7–1.86181.40.3–6.4
Pooled Analysis1105411278562.01.4–2.73073444585251.10.9–1.454531.10.6–2.1
Test for heterogeneity0.170.650.89
  • a OR adjusted for age, gender, and pack-years of tobacco smoking (and study in the pooled analysis).

  • b 95% CI.

  • c Wild type.

  • d OR adjusted for age, gender, asbestos, and pack-years of tobacco smoking (and study in the pooled analysis).

  • e Number of cases and controls exposed to asbestos and with GSTM1-null genotype.