Table 9

Examples of frequencies of observed genotype combinations compared to expected frequencies assuming nonlinkage

Genotype combinationRaceNo.ObservedExpected
GSTM1*0/*0 + GSTT1*0/*0Caucasian55320.1040.105
GSTM1*0/*0 + GSTT1*0/*0Asian4070.2460.248
GSTM1*0/*0 + CYP1A1*1/*2ACaucasian31920.05730.0558
GSTM1*0/*0 + CYP1A1*1/*2AAsian5090.1320.144
GSTM1*0/*0 + CYP1A1*2A/*2ACaucasian31920.00250.0028
GSTM1*0/*0 + CYP1A1*1/*2BCaucasian31920.03260.0341
GSTM1*0/*0 + CYP1A1*1/*2BAsian5090.1650.175
GSTM1*0/*0 + CYP1A1*2B/*2BAsian5090.02750.0245
GSTM1*0/*0 + CYP2E1*1/*5AAsian2830.2090.194
GSTM1*0/*0 + NAT2*5/*5Caucasian32660.1220.116
GSTM1*0/*0 + NAT2*6/*6Caucasian30690.04010.0370
GSTT1*0/*0 + CYP1A1*1/*2ACaucasian25020.01640.0207
GSTT1*0/*0 + CYP2E1*1/*6Caucasian3950.02530.0201
CYP1A1*1/*2A + NAT2*5/*5Caucasian13350.02170.0230
CYP1A1*1/*2B + (NAT2*4/*6 & NAT2*5/*6 & NAT2*6/*7)aCaucasian11510.02780.0276
CYP2E1*1/*6 + (NAT2*4/*5 & NAT2*5/*6 & NAT2*5/*7)bCaucasian4090.04160.0491
  • a Refers to all NAT2*6 heterozygotes.

  • b Refers to all NAT2*5 heterozygotes.