Table 3

Metabolic gene allele frequencies in different ethnic groups

GeneRaceNo.aHeterozygousHomozygousAllele
CYP1A1*1 Caucasians38140.190 (0.13–0.27)b0.795 (0.71–0.87)0.890
Asians6260.460 (0.43–0.49)0.395 (0.34–0.41)0.625
Africans4450.4650.4320.664
CYP1A1*2A Caucasians38140.105 (0.054–0.16)0.005 (0–0.015)0.058
Asians6260.272 (0.23–0.31)0.0128 (0–0.056)0.149
Africans4450.3330.05170.218
CYP1A1*2B Caucasians38140.064 (0.025–0.12)0.0001 (0–0.0057)0.032
Asians6260.331 (0.32–0.44)0.0463 (0.031–0.058)0.212
Africans4450.03600.018
CYP1A1*2C Caucasians38140.033 (0–0.095)0.0021 (0–0.012)0.0186
Asians6260.027 (0–0.032)0.0016 (0–0.012)0.0152
Africans4450.013500.00675
CYP1A1*3 Caucasians735000
Africans4640.1770.00430.0927
CYP2E1*5A Caucasians8540.048 (0.034–0.095)0.0012 (0–0.005)0.0252
Asians2860.367 (0.35–0.38)0.0594 (0.054–0.63)0.243
CYP2E1*5B Caucasians8540.0105 (0–0.05)00.00525
Asians2860.021 (0.006–0.045)00.0105
CYP2E1*6 Caucasians8540.102 (0.08–0.12)0.0023 (0–0.0032)0.0533
Asians2860.126 (0.071–0.093)00.0630
EPHX*3 Caucasians6850.3980.1170.316
EPHX*4 Caucasians6860.3530.0380.215
GSTM1*0 Caucasians105140.531 (0.42–0.60)
Asians15110.529 (0.42–0.54)
Africans4790.267 (0.16–0.36)
GSTT1*0 Caucasians55770.197 (0.13–0.26)
Asians5750.470 (0.35–0.52)
GSTM1*0 Caucasians55320.104
+T1*0Asians4070.246
GSTP1*1 Caucasians11370.4930.4380.685
GSTP1*2 Caucasians11380.4420.04130.262
GSTP1*3 Caucasians8780.1260.00570.0687
NAT2*5 Caucasians38470.482 (0.42–0.55)0.219 (0.13–0.32)0.46
NAT2*6 Caucasians36180.430 (0.35–0.56)0.070 (0.032–0.11)0.285
NAT2*7 Caucasians31290.055 (0.028–0.099)0.0013 (0–0.071)0.029
  • a No. refers to the number of subjects tested.

  • b Numbers in parentheses give the range of values for individual studies used.