Table 5

Covariance analysis of the relative changes of IGFs and IGFBPs after 1 year of intervention, by age

Data are expressed as the mean ratio (and 95% CI) between fenretinide and control adjusting for baseline values.
Fenretinide vs. Controlp
IGF-I
 ≤500.87 (0.75–1.01)0.288a
 >500.97 (0.84–1.13)0.122b
IGFBP-3
 ≤500.96 (0.88–1.06)0.999a
 >500.96 (0.88–1.06)0.250b
IGF-I/IGFBP-3
 ≤500.89 (0.78–1.01)0.170a
 >501.01 (0.89–1.16)0.274b
IGF-II
 ≤500.96 (0.86–1.08)0.486b
IGFBP-1
 ≤501.18 (0.87–1.59)0.287b
IGFBP-2
 ≤500.95 (0.72–1.25)0.728b
Free IGFsc
 ≤500.95 (0.84–1.08)0.466b
  • a P for the interaction between treatment and age.

  • b P for treatment.

  • c (IGF-I + IGF-II):(IGFBP-1 + IGFBP-2 + IGFBP-3) molar ratio.