Table 4

Relative changes of IGF-II, IGFBP-1, IGFBP-2, and total free IGFs ratio during the 5 years of intervention in women ≤50 years of age

Data are expressed as the mean ratio (and 95% CI) between baseline and yearly measurements.
IGF and yearFenretinideControl
nGeometric mean (95% CI)nGeometric mean (95% CI)
IGF-II
1250.97 (0.87–1.09)281.02 (0.94–1.11)
2211.07 (0.98–1.16)90.94 (0.77–1.16)
3170.94 (0.84–1.05)90.90 (0.72–1.13)
4141.01 (0.86–1.18)30.99 (0.87–1.12)
5100.92 (0.75–1.14)90.93 (0.85–1.02)
IGFBP-1
1251.06 (0.80–1.42)280.87 (0.68–1.11)
2211.26 (0.91–1.73)90.64 (0.42–0.96)
3171.04 (0.68–1.59)90.70 (0.43–1.14)
4141.26 (0.92–1.72)40.96 (0.57–1.62)
5101.53 (0.82–2.85)90.91 (0.64–1.29)
IGFBP-2
1251.05 (0.82–1.35)281.06 (0.91–1.24)
2201.10 (0.86–1.41)91.16 (0.94–1.42)
3151.05 (0.82–1.33)91.17 (0.82–1.68)
4111.08 (0.78–1.50)40.84 (0.70–0.99)
5100.94 (0.67–1.31)91.04 (0.75–1.46)
Free IGFsa
1251.04 (0.93–1.17)271.08 (0.99–1.19)
2201.18 (1.06–1.32)81.00 (0.87–1.16)
3151.00 (0.89–1.12)81.11 (0.87–1.41)
4111.12 (0.98–1.27)30.91 (0.84–0.98)
5101.01 (0.83–1.22)90.96 (0.84–1.10)
  • a (IGF-I + IGF-II):(IGFBP-1 + IGFBP-2 + IGFBP-3) molar ratio.